BPTF — Bromodomain PHD finger transcription factor
BPTF belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BPTF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal center B-cell B cell maturation | BACH2, BCL6, GGA2, MAP4K4, MBD4, MCTP2, MSI2, NR3C1 +7 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Remodeling Signaling DNA/chromatin regulation | AKAP13, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, DOCK10, FBXW7 +23 more | |
| Glial cells | ECM Homeostatic Regulation ECM remodeling | KCTD12, MAPRE2, OAF, SASH1, ST3GAL6, TIMP2, TTC3 | View in SCUBA |
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | BAZ2B, GTF2I, INSR, MYO10, PDZD8, RERE, TOP2B, ZKSCAN1 | View in SCUBA |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BCLAF1, CBL, CDK13, IQGAP2, KDM2A, KDM5A, LTC4S, MACF1 +8 more | View in SCUBA |
| Lymphatic endothelial | Pre-mRNA Splicing RNA processing & translation | ARGLU1, ATRX, DDX17, DST, LUC7L3, N4BP2L2, NKTR, PNISR +6 more | View in SCUBA |
| Macrophages | Chromatin Regulatory Genes Housekeeping | ACAP2, ARID4A, ATRX, BRD10, BRD4, EP300, ERBIN, ETNK1 +31 more | View in SCUBA |
About the gene
| Synonyms | FAC1, FALZ, NURF301 |
|---|---|
| Chromosome | 17: 67825503-67984378 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Transcription, Transcription regulation |
Function
Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.