ABCF1 — ATP binding cassette subfamily F member 1
ABCF1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A, GNL3 +21 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABHD12, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP, INPP4A +18 more | |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, DNAJC7, EIF2S2 +37 more | View in SCUBA |
| Macrophages | RNA Splicing Regulation Housekeeping | CDC42SE1, CDC5L, CDV3, CEBPZ, DNAJC7, DYNC1LI1, FGFR1OP2, GNL3 +13 more | View in SCUBA |
About the gene
| Synonyms | ABC50, EST123147 |
|---|---|
| Chromosome | 6: 30571393-30597179 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Activator |
Function
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.