Chromatin-Coupled Splicing
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 45 genes have a known function matching the annotation |
Why this annotation
Hub gene BPTF is the large subunit of the NURF chromatin remodeling complex (ISWI family). NSD3 is a histone H3K36 methyltransferase, ARID1B is a SWI/SNF chromatin remodeling subunit, SON is a chromatin-associated splicing factor. SRSF4, RBM25, DDX46, DDX24, SF3B1, SMNDC1 are all splicing factors. YTHDC1 is an m6A reader that regulates alternative splicing. GNL2 is involved in ribosome biogenesis. CHEK2 is a DNA damage checkpoint kinase. The module combines chromatin remodeling with splicing regulation — consistent with co-transcriptional splicing control via chromatin state. Strong coherence with uniform expression.
Genes
Most correlated modules
- Splicing Regulation · correlation 0.88
- Pre-mRNA Splicing · correlation 0.87
- Spliceosome Assembly · correlation 0.86
- ER-Golgi Trafficking · correlation 0.84
- Chromatin Transcriptional Control · correlation 0.84
- Transcription-Coupled Splicing · correlation 0.83
- Actin Cytoskeletal Regulation · correlation 0.81
- Focal Adhesion Migration · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.