CKAP5 — Cytoskeleton associated protein 5

CKAP5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CKAP5's module in each cell type

Cell type	Module	Shares the module with
Gamma-delta T cells	Mitotic Spindle Cell cycle	CAPRIN1, CDK5RAP2, CNTRL, DEK, DNMT1, FAM111A, GMPS, HADH +11 more
Goblet cells	Mitotic Spindle Assembly Cell cycle	ARHGAP11A, AURKA, CDKN3, CENPA, CKS2, FAM83D, KIF14, KNL1 +5 more	View in SCUBA
Macrophages	Centrosome & DNA Repair Cell cycle	ANKRD13A, BRCA2, CASP2, CBX5, CCDC14, CEP152, CEP78, CSE1L +34 more	View in SCUBA

About the gene

Synonyms	ch-TOG, KIAA0097, TOG, TOGp
Chromosome	11: 46743048-46846308
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Biological process	Cell cycle, Cell division, Mitosis

Function

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as a processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.