Mitochondrial RNA Processing
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub gene POLG (mitochondrial DNA polymerase gamma) alongside PMPCB (mitochondrial processing peptidase), MRPS30 (mitochondrial ribosomal protein S30), and DARS1 (aspartyl-tRNA synthetase) clearly indicate mitochondrial biogenesis/maintenance. SON, PRPF38B, RBMX, SMNDC1, WDR33 are pre-mRNA splicing factors. VCP (AAA-ATPase for protein unfolding/ER-associated degradation) and PDCD4 (translation inhibitor/pro-apoptotic) add protein processing. The module is moderate coherence combining mitochondrial maintenance with RNA processing, likely reflecting a shared transcriptional activity state. Neighbor context with M92 (splicing) and M116 (chromatin) supports overlapping basal regulatory programs.
Genes
ABR, DARS1, DENND1C, GTDC1, MRPS30, PDCD4, PMPCB, POLG, PRKD2, PRPF38B, RBMX, SIDT1, SMNDC1, SON, SUSD6, TMEM183A, TSPOAP1, USP11, VCP, WDR33
Most correlated modules
- Spliceosome Regulation · correlation 0.86
- Centrosome Organization · correlation 0.83
- Autophagy Stress Response · correlation 0.82
- T Cell Phosphatase Signaling · correlation 0.82
- NK/T Cell Identity · correlation 0.82
- Wnt-STAT3 Signaling · correlation 0.80
- T Cell Migration · correlation 0.80
- Chromatin Remodeling Signaling · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.