PMPCB — Peptidase, mitochondrial processing subunit beta
PMPCB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PMPCB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial RNA Processing Mitochondrial & OxPhos | ABR, DARS1, DENND1C, GTDC1, MRPS30, PDCD4, POLG, PRKD2 +11 more | |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E +18 more | View in SCUBA |
About the gene
| Synonyms | beta-MPP, MAS1, MPPB, MPPP52 |
|---|---|
| Chromosome | 7: 103297407-103331818 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.