H2BC15 — H2B clustered histone 15
H2BC15 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2BC15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Natural Killer cells | Replication-Coupled Histones Cell cycle | H1-10, H1-2, H1-3, H1-4, H2AC6, H2AC8, H2BC4, H4C3 | View in SCUBA |
About the gene
| Synonyms | H2B/d, H2BFD, HIST1H2BN |
|---|---|
| Chromosome | 6: 27838545-27855709 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.