H1-3 — H1.3 linker histone, cluster member
H1-3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H1-3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | ILC3 identity Differentiation | ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more | View in SCUBA |
| Monocytes | Histone Chromatin Remodeling Housekeeping | CTSD, H1-10, H1-2, H1-4, H2AJ, H4C3, HMGB2, HOXA9 | View in SCUBA |
| Natural Killer cells | Replication-Coupled Histones Cell cycle | H1-10, H1-2, H1-4, H2AC6, H2AC8, H2BC15, H2BC4, H4C3 | View in SCUBA |
About the gene
| Synonyms | H1.3, H1d, H1F3, H1s-2, HIST1H1D |
|---|---|
| Chromosome | 6: 26234212-26234987 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.