H2BC4 — H2B clustered histone 4
H2BC4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2BC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Natural Killer cells | Replication-Coupled Histones Cell cycle | H1-10, H1-2, H1-3, H1-4, H2AC6, H2AC8, H2BC15, H4C3 | View in SCUBA |
About the gene
| Synonyms | H2B.1, H2B/l, H2BFL, HIST1H2BC |
|---|---|
| Chromosome | 6: 26114873-26123926 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Antibiotic, Antimicrobial, DNA-binding |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.