H2AC6 — H2A clustered histone 6
H2AC6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
H2AC6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | JUN stress response Stress | FOXO3, H1-2, JUN, LAMA3, LAMB3, PTPRB, ZNF292 | View in SCUBA |
| Innate lymphoid cells | Septin Cytoskeleton Cytoskeleton & motility | ATP6V0C, C17orf49, CIAO2A, COX16, DARS1, DDOST, GET3, H3-3B +18 more | View in SCUBA |
| Macrophages | Integrated Stress Response Stress | AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD +17 more | View in SCUBA |
| Natural Killer cells | Replication-Coupled Histones Cell cycle | H1-10, H1-2, H1-3, H1-4, H2AC8, H2BC15, H2BC4, H4C3 | View in SCUBA |
| Neutrophils | S100 Alarmin Response Inflammatory | CD177, METTL9, MS4A6A, RBP7, S100A12, S100A4, S100A6, SH3BGRL3 |
About the gene
| Synonyms | H2AFL, HIST1H2AC |
|---|---|
| Chromosome | 6: 26124145-26139116 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.