Replication-Coupled Histones
Gene co-expression module in Natural Killer cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
All 9 genes are canonical histones: H1-2, H1-3, H1-4, H1-10 are linker histone H1 variants; H2BC4, H2BC15 are histone H2B; H2AC8, H2AC6 are histone H2A; H4C3 is histone H4. These are replication-coupled core and linker histones expressed during S-phase. The complete absence of any disease response signal (all deltas = 0.000) and uniform expression suggest a cell-cycle S-phase housekeeping program. Neighbors M37 and M47 also contain histones, confirming a chromatin gene neighborhood.
Genes
H1-10, H1-2, H1-3, H1-4, H2AC6, H2AC8, H2BC15, H2BC4, H4C3
Most correlated modules
- Replication Histones · correlation 0.84
- Histone Variant Remodeling · correlation 0.82
- Mitochondrial Membrane Organization · correlation 0.70
- Septin Cytoskeletal Assembly · correlation 0.66
- Interferon NK Activation · correlation 0.65
- Mitotic Spindle · correlation 0.64
- S-phase Replication · correlation 0.59
- Housekeeping Mixed · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.