HEG1 — Heart development protein with EGF like domains 1
HEG1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HEG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | BCAM, CRIP2, EPAS1, FES, IFI27, IFITM1, LIMA1, LIMS2 +8 more | View in SCUBA |
| Monocytes | Type I Interferon Response Antiviral | IFITM1, IRF9, LY6E, MYOF, OAS1, PLAAT4, PSMB10, WARS1 | View in SCUBA |
About the gene
| Synonyms | HEG, KIAA1237 |
|---|---|
| Chromosome | 3: 124965710-125055997 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
Function
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.