EPAS1 — Endothelial PAS domain protein 1
EPAS1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPAS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | BCAM, CRIP2, FES, HEG1, IFI27, IFITM1, LIMA1, LIMS2 +8 more | View in SCUBA |
| Fibroblasts | Hypoxia Response Stress | ACSL4, AP2S1, ARFGAP3, C4orf48, HIF1A, IL4R, ISG20, NECTIN2 +8 more | View in SCUBA |
| Gamma-delta T cells | Hypoxia Tissue Adaptation Tissue residence | ABCB1, ADAMTS17, ANKRD28, CCRL2, FAM3C, KLHL6, LDLRAD4, PHTF1 +10 more | |
| Lymphatic endothelial | IL33 Alarmin Response Inflammation | CLIC4, HRCT1, IGFBP5, IL33, LIFR, PLAT, PLSCR1, PRELP +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Cell Identity T cell maturation | AFF3, DDX3Y, DKK3, DSE, FKBP5, FYN, GLIPR1, H1-10 +16 more | |
| Natural Killer cells | Hypoxia Response Stress | ANKRD28, ATP8B4, HIP1, LPIN1, MAML3, MDFIC, RGS1, RHOQ +2 more | View in SCUBA |
| Smooth muscle cells | Vascular Tone Signaling Contractility | ADCY3, CPEB4, CYSTM1, DBI, EPS8, IER5L, NR2F2, PDE3A +5 more | View in SCUBA |
About the gene
| Synonyms | bHLHe73, HIF2A, HLF, MOP2, PASD2 |
|---|---|
| Chromosome | 2: 46293667-46386697 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Angiogenesis, Differentiation, Host-virus interaction, Transcription, Transcription regulation |
Function
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.