BCAM — Basal cell adhesion molecule (Lutheran blood group)
BCAM belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCAM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | CRIP2, EPAS1, FES, HEG1, IFI27, IFITM1, LIMA1, LIMS2 +8 more | View in SCUBA |
| Smooth muscle cells | Vascular SMC Identity Contractility | ADIRF, ARPC1A, CCDC3, CRIP1, EFHD1, GPRC5C, GPX3, HRC +10 more | View in SCUBA |
About the gene
| Synonyms | CD239, LU |
|---|---|
| Chromosome | 19: 44809071-44821421 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Blood group antigen proteins, CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Blood group antigen, Receptor |
| Biological process | Cell adhesion |
Function
Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.