LIMS2 — LIM zinc finger domain containing 2
LIMS2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIMS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | BCAM, CRIP2, EPAS1, FES, HEG1, IFI27, IFITM1, LIMA1 +8 more | View in SCUBA |
| Fibroblasts | Smooth Muscle Differentiation Developmental | ADCY5, ASB2, CABP1, CKB, DYSF, FLNC, PGM5, TMEM35A | View in SCUBA |
| Smooth muscle cells | Microtubule biogenesis Cytoskeletal | ACOT7, FBXL22, ILF2, NUCB2, PGRMC1, PHGDH, PPP2R1A, TBCB +3 more | View in SCUBA |
About the gene
| Synonyms | PINCH-2, PINCH2 |
|---|---|
| Chromosome | 2: 127638381-127681786 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.