FES — FES proto-oncogene, tyrosine kinase
FES belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FES's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | BCAM, CRIP2, EPAS1, HEG1, IFI27, IFITM1, LIMA1, LIMS2 +8 more | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FCER1G, FUCA1, GEM, GRAMD2B, HMOX1 +14 more | |
| Innate lymphoid cells | ILC1 Effector Activation activation | ADAM19, ARHGEF3, BATF, CD151, CDK4, FURIN, HLA-F, IL22 +16 more | View in SCUBA |
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more | View in SCUBA |
About the gene
| Synonyms | FPS |
|---|---|
| Chromosome | 15: 90883695-90895776 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Function
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.