IFITM1 — Interferon induced transmembrane protein 1
IFITM1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IFITM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Hypoxia-IFN Endothelial Endothelial cell development | BCAM, CRIP2, EPAS1, FES, HEG1, IFI27, LIMA1, LIMS2 +8 more | View in SCUBA |
| Gamma-delta T cells | Effector IFN Response cytotoxicity | AGTRAP, ANXA1, B2M, CYBA, EMP3, FXYD5, GZMM, IFITM2 +9 more | |
| Innate lymphoid cells | Interferon-Stimulated Genes Inflammation | ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GNB2, GRINA +17 more | View in SCUBA |
| Monocytes | Type I Interferon Response Antiviral | HEG1, IRF9, LY6E, MYOF, OAS1, PLAAT4, PSMB10, WARS1 | View in SCUBA |
| Mucosal-associated invariant T cell | NADPH Oxidase & Innate Immune Inflammation | ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GABARAP, GNG5, HIGD2A +9 more | |
| Natural Killer cells | Interferon NK Activation Inflammation | CYRIB, KLRK1, NHERF1, PLAAT4, RNASEK, SEPTIN9, TLE5, UBE2V1 | View in SCUBA |
| Smooth muscle cells | Type I Interferon Inflammation | BST2, GBP4, HLA-F, IFI6, IFIT2, ISG15, LY6E, PSMB8 +3 more | View in SCUBA |
About the gene
| Synonyms | 9-27, CD225, DSPA2a, IFI17 |
|---|---|
| Chromosome | 11: 310041-315272 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Antiviral defense, Immunity, Innate immunity, Osteogenesis |
Function
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Inhibits SARS-CoV-2 S protein- mediated syncytia formation. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.