HS2ST1 — Heparan sulfate 2-O-sulfotransferase 1
HS2ST1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HS2ST1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
About the gene
| Synonyms | KIAA0448 |
|---|---|
| Chromosome | 1: 86914635-87109982 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
Function
Catalyzes the transfer of a sulfo group from 3'-phospho-5'- adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis (By similarity). Required for metanephric development of kidney formation, suggesting that 2-O- sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.