IL18RAP — Interleukin 18 receptor accessory protein
IL18RAP belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL18RAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine receptor signaling Immune regulation | C21orf91, C6orf62, DDX3X, HNRNPH1, ID2, IL15RA, MMD, PERP +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | IL-18 Innate Activation Inflammation | ADAM10, COLQ, KIF5C, ME1, MYBL1, NEO1, P2RY14, PARP8 +3 more | |
| Neutrophils | Ubiquitin-Proteasome Turnover Housekeeping | BLTP3B, CACUL1, CLIP1, FBXL20, FBXO33, FGD3, KIF13A, LMTK2 +10 more |
About the gene
| Synonyms | AcPL, CD218b |
|---|---|
| Chromosome | 2: 102418689-102452565 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Receptor |
| Biological process | Inflammatory response |
Function
Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.