PARP8 — Poly(ADP-ribose) polymerase family member 8

PARP8 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PARP8's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Cytotoxic Effector CD4 Cytotoxicity	ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2 +13 more	View in SCUBA
Enterocytes	IFN-gamma STAT1 signaling Inflammation	C2, ENSG00000283782, GBP4, HLA-E, LAP3, NLRC5, STAT1, TAP1 +1 more	View in SCUBA
Gamma-delta T cells	TCR Inhibitory Signaling Exhaustion	AFF4, CBLB, CCNH, CCNT1, CHD2, CRYBG1, FYN, ISG20 +9 more
Innate lymphoid cells	ILC3 identity Differentiation	ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more	View in SCUBA
Macrophages	MITF Lysosomal Program Lysosomal & pahgocytosis	ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, DCTN4 +25 more	View in SCUBA
Mucosal-associated invariant T cell	IL-18 Innate Activation Inflammation	ADAM10, COLQ, IL18RAP, KIF5C, ME1, MYBL1, NEO1, P2RY14 +3 more
Natural Killer cells	Inflammatory Stress Response Stress	AKIRIN2, CCNH, CEBPD, CLASP1, FKBP5, H3C1, P2RX5, PIK3IP1 +2 more	View in SCUBA
Neutrophils	Stress Kinase Signaling Stress	ANKRD44, APBB1IP, HIPK3, IGF1R, MAP3K5, MEF2A, NEK7, RAP1GAP2 +2 more

About the gene

Synonyms	ARTD16, FLJ21308, pART16
Chromosome	5: 50665899-50846519
Predicted location	Intracellular
Essential gene	No
Protein class	Metabolic proteins, Predicted intracellular proteins
Molecular function	Glycosyltransferase, Nucleotidyltransferase, Transferase

Function

Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.