MYBL1 — MYB proto-oncogene like 1
MYBL1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYBL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Dark-zone GC B-cell B cell maturation | BRWD1, CCDC144A, CCDC88A, CD38, FGD6, LPP, MYO1E, RAPGEF5 +2 more | View in SCUBA |
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44 +12 more | View in SCUBA |
| CD8⁺ T cells | Naive/Memory CD8 T cell maturation | C1orf162, CD48, CD55, EEF1B2, GPR155, IL7R, MATK, NACA +3 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Signaling Immune regulation | ABCF1, ABHD12, ACAP2, ADIPOR2, CBX6, ENPP4, FBXO9, GSAP +18 more | |
| Mucosal-associated invariant T cell | IL-18 Innate Activation Inflammation | ADAM10, COLQ, IL18RAP, KIF5C, ME1, NEO1, P2RY14, PARP8 +3 more |
About the gene
| Synonyms | A-myb, AMYB |
|---|---|
| Chromosome | 8: 66562175-66614247 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Differentiation, Spermatogenesis, Transcription, Transcription regulation |
Function
Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.