IL23A — Interleukin 23 subunit alpha
IL23A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL23A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Unfolded Protein Response Protein processing & ER | ARF4, ATF4, DUSP8, HSPA5, NLRP3, NOP56, NRIP3, NXT1 +7 more | View in SCUBA |
About the gene
| Synonyms | IL-23, IL-23A, IL23P19, P19, SGRF |
|---|---|
| Chromosome | 12: 56334174-56340410 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling |
Function
Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro- inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.