NXT1 — Nuclear transport factor 2 like export factor 1
NXT1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NXT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing factors RNA processing | CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, HNRNPAB +12 more | View in SCUBA |
| CD4⁺ T cells | Unfolded Protein Response Protein processing & ER | ARF4, ATF4, DUSP8, HSPA5, IL23A, NLRP3, NOP56, NRIP3 +7 more | View in SCUBA |
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more | |
| Lymphatic endothelial | Notch TGF-β Endothelial endothelial development | ARF6, ARL4C, C16orf87, CCNL1, CLK1, DEDD2, ELOC, GPBP1 +11 more | View in SCUBA |
| Macrophages | Integrated Stress Response Stress | AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD +17 more | View in SCUBA |
| Monocytes | Immediate Early Activation Stress | ARRDC2, GALR2, IER5L, MRPL55, MTSS1, NDUFA12, RRAS, SLC7A7 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Stress UPR Stress | DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, LDHA +9 more |
About the gene
| Synonyms | MTR2, P15 |
|---|---|
| Chromosome | 20: 23350791-23354771 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.