DUSP8 — Dual specificity phosphatase 8
DUSP8 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DUSP8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activation/Migration BCR/AP1/NFKb pathway | AHNAK, DUSP10, GGA1, GPR183, GPR65, IDS, KLF6, LDLRAD4 +11 more | View in SCUBA |
| CD4⁺ T cells | Unfolded Protein Response Protein processing & ER | ARF4, ATF4, HSPA5, IL23A, NLRP3, NOP56, NRIP3, NXT1 +7 more | View in SCUBA |
| Gamma-delta T cells | Late Activation Autophagy Immune regulation | BCL3, BRD1, CREM, FAM177A1, FBXO33, FOSL2, GABARAPL1, IRF2BP2 +19 more | |
| Mucosal-associated invariant T cell | NF-κB Activation Inflammation | DUSP5, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1, PER1 +8 more | |
| Natural Killer cells | Circadian NF-κB Crosstalk Inflammation | IRF2BP2, ISCA1, MAP3K8, MED10, PER1, RELB, RHOH, SLC7A5 | View in SCUBA |
| Smooth muscle cells | NR4A-ADAMTS Activation Stress | ADAMTS1, ADAMTS4, ADAMTS9, AVPR1A, HIPK2, KLF9, MYC, NR4A1 +5 more | View in SCUBA |
About the gene
| Synonyms | C11orf81, FLJ42958, HB5, HVH-5 |
|---|---|
| Chromosome | 11: 1554051-1572271 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.