IRF4 — Interferon regulatory factor 4
IRF4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IRF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell activation TCR/AP1/NFKb pathway | ANKS1B, ARF6, CCT6A, EHD4, HNRNPM, MAP2K3, PFDN2, TRIB1 +3 more | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B +14 more |
About the gene
| Synonyms | LSIRF, MUM1 |
|---|---|
| Chromosome | 6: 391739-411443 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.