APOA4 — Apolipoprotein A4
APOA4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Chylomicron apolipoprotein assembly Lipid metabolism | APOA1, APOC3, ARG2, CYP3A4, ENPP3, FLVCR1, RMDN3, THSD4 | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B, HMOX1 +14 more |
About the gene
| Chromosome | 11: 116820700-116823304 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins |
| Biological process | Lipid transport, Transport |
Function
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.