FCER1G — Fc epsilon receptor Ig
FCER1G belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCER1G's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FES, FUCA1, GEM, GRAMD2B, HMOX1 +14 more | |
| Innate lymphoid cells | NK Receptor Signaling Cytotoxicity | B2M, CD48, CLEC2B, DCK, FKBP11, GPR108, HLA-A, HLA-B +12 more | View in SCUBA |
| Macrophages | MHC-II Antigen Presentation Innate immunity | AIF1, B2M, C1QA, C1QB, C1QC, CD68, CD74, CST3 +19 more | View in SCUBA |
| Monocytes | Monocyte Immune Tolerance Tissue adaptation | ATP1B3, CTSL, EMP1, FTH1, HAVCR2, INSIG1, MALT1, TIMP1 +1 more | View in SCUBA |
| Natural Killer cells | NK Inflammatory Activation Inflammation | BST2, CCT4, FGFR1OP2, ITM2B, LPIN2, LPXN, MBNL1, PTGES3 +1 more | View in SCUBA |
| Neutrophils | Phagocytic Membrane Signaling Phagocytosis | APLP2, ATP6V1B2, CD44, CDC42EP3, CLIC1, EFHD2, FLOT1, GRINA +9 more |
About the gene
| Synonyms | FcepsilonRIgamma |
|---|---|
| Chromosome | 1: 161215234-161220699 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted membrane proteins |
| Molecular function | IgE-binding protein, Receptor |
| Biological process | Immunity, Innate immunity |
Function
Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'- dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen- specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.