IRF4 T-cell Activation
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 23 genes have a known function matching the annotation |
Why this annotation
TNFRSF18 (GITR) and IRF4 are canonical T cell activation/regulatory markers. GEM (Gem GTPase) is associated with T cell anergy and negative regulation. SH2D1B (EAT-2) links to NK/T cell activating receptor signaling. FCER1G (FcRγ) is expressed on NK-like T cells. HMOX1 indicates oxidative stress adaptation. LAT2 participates in activating receptor signaling. APOA1/APOA4 are likely peripheral members. The module best represents an IRF4-driven T cell activation/regulatory state, consistent with gd T cell effector differentiation.
Genes
APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B, HMOX1, HNRNPAB, HPRT1, IRF4, JPT1, KLHL23, KRT86, LAT2, LAYN, RANGAP1, RUVBL2, SH2D1B, SLC16A3, TNFRSF18, ZDHHC14
Most correlated modules
- Hypoxia Tissue Adaptation · correlation 0.84
- AHR/NF-κB Survival · correlation 0.82
- S-phase Proliferation · correlation 0.78
- T Cell Exhaustion · correlation 0.72
- Tissue Resident CD103+ · correlation 0.71
- Gut-homing Residence · correlation 0.69
- Cholesterol Biosynthesis · correlation 0.66
- Immature T Cell · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.