KYNU — Kynureninase
KYNU belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KYNU's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Monocyte Lipid Metabolism Lipid metabolism | ATP13A3, CEP170, CHIC2, COQ10B, CSGALNACT2, ENOSF1, HIPK2, HMGXB3 +14 more | View in SCUBA |
| Monocytes | Inflammasome Activation Innate immunity | ATG3, CARD16, CASP1, CASP4, CD48, CD53, MTHFD2, PSMA4 +1 more | View in SCUBA |
About the gene
| Chromosome | 2: 142877657-143055833 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Pyridine nucleotide biosynthesis |
Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.