Wound Regenerative Response
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 45 genes have a known function matching the annotation |
Why this annotation
This module is strongly enriched in inf_colono and upregulated in UC inflammation. Hub genes include KRT7 (keratin 7, squamous/metaplastic marker), KRT6B (keratin 6B, wound/stress keratin), CDH3 (P-cadherin, epithelial remodeling), MMP7 (matrilysin, epithelial injury/remodeling), TRIB2 (tribbles pseudokinase, stress/EMT), KYNU (kynureninase, tryptophan metabolism), IL1RN (IL-1 receptor antagonist), IL1B (interleukin-1 beta), ITGA2 (integrin alpha-2, wound healing), SERPINB5 (maspin), PHLDA1 (stress response), FSTL1 (follistatin-like, TGF-beta signaling). The combination of wound-associated keratins (KRT6B, KRT7), MMP7, and inflammatory cytokines (IL1B, IL1RN) strongly suggests an epithelial wound response/regenerative program in inflamed colonocytes, consistent with regenerative or metaplastic colonocytes seen in IBD.
Genes
Most correlated modules
- Epithelial Innate Immunity · correlation 0.87
- Oxidative Inflammatory Remodeling · correlation 0.85
- Inflammatory Stress Response · correlation 0.84
- IFN-gamma Response · correlation 0.83
- Hypoxia-Inflammatory Reprogramming · correlation 0.76
- MHC II Antigen Presentation · correlation 0.76
- Inflammatory Regenerative State · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.