Monocyte Lipid Metabolism
Gene co-expression module in Macrophages
| Category | Lipid metabolism |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
Strong mono_mac enrichment across most genes. TOM1, PLEKHM2, KIF13A, NUMB, PSD3, and ATP13A3 are all endosomal/lysosomal trafficking components. PLIN2 marks lipid droplet formation. SLC37A2 is a macrophage-specific glucose-6-phosphate transporter linked to lipid metabolism. KYNU encodes kynureninase in tryptophan catabolism, a known immunomodulatory pathway in macrophages. VAV3 and MTSS1 contribute cytoskeletal/migratory context. The module reflects a monocyte-derived macrophage program integrating endosomal trafficking with lipid and tryptophan metabolism.
Genes
ATP13A3, CEP170, CHIC2, COQ10B, CSGALNACT2, ENOSF1, HIPK2, HMGXB3, KIF13A, KYNU, MTSS1, NUMB, PGS1, PLEKHM2, PLIN2, PSD3, SLC36A4, SLC37A2, TOM1, USP12, USP3, VAV3, VRK2
Most correlated modules
- Microtubule Organization · correlation 0.95
- Transcriptional Regulation · correlation 0.94
- Transcriptional Regulation · correlation 0.92
- NF-κB AP-1 Signaling · correlation 0.92
- Transcriptional Repression · correlation 0.92
- Osmotic Stress Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.