MAEA — Macrophage erythroblast attacher, E3 ubiquitin ligase
MAEA belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAEA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ATF7IP2, ATP10D, B3GALT2, COMMD8, GBP3, GFI1, GPR34, MGAT1 +7 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CAMK4, CCL5, CCNG2, CD247, CD3E +17 more | View in SCUBA |
About the gene
| Synonyms | EMP, GID9, HLC-10, p44EMLP |
|---|---|
| Chromosome | 4: 1289887-1340147 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Actin-binding, Transferase |
| Biological process | Cell cycle, Cell division, Erythrocyte maturation, Ubl conjugation pathway |
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.