CAMK4 — Calcium/calmodulin dependent protein kinase IV
CAMK4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAMK4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ADA2, ANK3, CHD7, GCLM, GNAO1, MPP7, NME4 +15 more | View in SCUBA |
| Fibroblasts | Intestinal Fibroblast Identity Developmental | ABR, AFF3, ATP8A1, ATP9A, DSE, ENPP2, GLP2R, MRPS6 +7 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CASK, CCR5, CD84, CDC14A, CXCR6, DGKA +22 more | |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CCL5, CCNG2, CD247, CD3E, DCXR +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT4 T cell Identity T cell maturation | ATF7IP, CBLB, CD96, CELF2, DENND4A, IKZF1, JMJD1C, PIP4K2A +7 more | |
| Natural Killer cells | Tissue-Resident NK Gut residency | ADRB1, GPR34, GPR55, ITGAE, LRRC25, MYO1E, NCR2, S100A13 +2 more | View in SCUBA |
About the gene
| Synonyms | CaMK-GR, CaMKIV |
|---|---|
| Chromosome | 5: 111223653-111494886 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Adaptive immunity, Immunity, Inflammatory response |
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.