CD247 — CD247 molecule
CD247 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD247's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell exhaustion Exhaustion | CD38, CD59, FLT1, GAN, IKBKB, LAG3, LRBA, PTMS +3 more | View in SCUBA |
| CD8⁺ T cells | Terminal Exhaustion Exhaustion | ACP5, CARD16, CASP1, CD2, CD8A, CD8B, CHST12, CXCR6 +6 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CAMK4, CCL5, CCNG2, CD3E, DCXR +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CHD9, CLCN3, DDX17, FLI1 +14 more | |
| Natural Killer cells | NK Cytotoxic Activation Cytotoxicity | ABI3, ALOX5AP, ARHGDIB, BPGM, GNPTAB, GZMA, HCLS1, LAT2 +3 more | View in SCUBA |
About the gene
| Synonyms | CD3-ZETA, CD3H, CD3Q, CD3Z, CD3ZETA, TCRZ |
|---|---|
| Chromosome | 1: 167425027-167518640 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Host-virus interaction, Immunity |
Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.