CCL5 — C-C motif chemokine ligand 5
CCL5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM, MCOLN2 +12 more | View in SCUBA |
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CHD9, DPP4, HIC1, HOPX, IFIT2, ITGA1 +13 more | View in SCUBA |
| CD8⁺ T cells | Cytotoxic Effector cytotoxicity | APOBEC3H, B2M, CCL4, CD52, CYBA, GZMH, HCST, HLA-A +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Platelet Biogenesis Myeloid development | CAVIN2, CMTM5, F13A1, GNG11, GP9, MAP3K7CL, NRGN, PF4 +6 more | |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CAMK4, CCNG2, CD247, CD3E, DCXR +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mature Effector MAIT T cell maturation | ADD3, ANTKMT, APOBEC3G, CXXC5, FHL3, GZMK, ITGA6, ITGB2 +7 more |
About the gene
| Synonyms | D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228 |
|---|---|
| Chromosome | 17: 35871491-35880793 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.