MCUR1 — Mitochondrial calcium uniporter regulator 1
MCUR1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCUR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitochondrial Metabolic Stress Mitochondrial & OxPhos | AFAP1, DHRS7B, LDHA, MRPL9, NDUFA8, NUCB2, OAZ3, PRKACA +3 more | View in SCUBA |
| Gamma-delta T cells | Cellular Homeostasis Housekeeping | ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more |
About the gene
| Synonyms | C6orf79, CCDC90A, FLJ20958 |
|---|---|
| Chromosome | 6: 13786557-13814568 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.