Mitochondrial Metabolic Stress
Gene co-expression module in Endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes MRPL9 (mitochondrial large ribosomal subunit), MCUR1 (mitochondrial calcium uniporter regulator), and NDUFA8 (NADH:ubiquinone oxidoreductase subunit, Complex I) anchor this module in mitochondrial function. LDHA encodes lactate dehydrogenase A, a key glycolytic enzyme upregulated during metabolic stress. NUCB2 and RCN2 are ER calcium-binding proteins. PRKACA (PKA catalytic subunit) regulates mitochondrial function and metabolism. UBE2F is a ubiquitin-conjugating enzyme. SNAP23 mediates vesicle fusion. AFAP1 links to actin. The module shows modest but significant inflammation upregulation (0.23 UC), suggesting metabolic adaptation rather than primary inflammatory activation. In the context of neighboring modules, this represents the mitochondrial/metabolic stress adaptation component of the inflammatory endothelial response.
Genes
AFAP1, DHRS7B, LDHA, MCUR1, MRPL9, NDUFA8, NUCB2, OAZ3, PRKACA, RCN2, SNAP23, UBE2F
Most correlated modules
- Hypoxia Response · correlation 0.81
- ER-Golgi Trafficking · correlation 0.78
- Actin Cytoskeletal Remodeling · correlation 0.78
- Immune Cell Contamination · correlation 0.77
- NF-κB Oxidative Stress · correlation 0.76
- Endothelial Quiescence Identity · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.