Cellular Homeostasis
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 30 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 19 of 30 genes have a known function matching the annotation |
Why this annotation
This module contains a broad mix of housekeeping genes involved in diverse metabolic and cellular maintenance functions: PRDX3 (mitochondrial peroxiredoxin/redox homeostasis), FDPS (isoprenoid/cholesterol biosynthesis), GSTO1 (glutathione transferase), PSMA4 (proteasome subunit), MDH1 (malate dehydrogenase/TCA cycle), SLC25A11 (mitochondrial carrier), UQCC2 (ubiquinol-cytochrome c reductase assembly), DPM2 (dolichol-phosphate mannose synthase), RANBP1 (RAN GTPase binding/nuclear transport), LSM3 (RNA processing), RNASEH2C (RNase H2/DNA damage), CBX3 (HP1 gamma/chromatin), HMGN2 (nucleosome binding), BANF1 (nuclear envelope), DUT (dUTPase), MACROH2A1 (histone variant), ANAPC11 (APC/C ubiquitin ligase), COMMD4 (COMM domain/copper metabolism), LAGE3 (tRNA modification), MEA1 (male-enhanced antigen). These genes reflect basal cellular homeostasis across multiple compartments rather than a single tight program. The uniform expression and moderate mean expression support constitutive housekeeping activity. Neighbor context: this module is topologically adjacent to cell-cycle modules (M184, M86, M83, M88), consistent with shared baseline proliferative/metabolic activity.
Genes
ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT, FDPS, GSTO1, HMGN2, IFT25, LAGE3, LSM3, MACROH2A1, MAD2L2, MCUR1, MDH1, MEA1, MRPS12, PAFAH1B3, POLR2E, PRDX3, PSMA4, RANBP1, RNASEH2C, SHMT2, SLC25A11, UQCC2, UQCRC1
Most correlated modules
- Mitochondrial OxPhos · correlation 0.90
- Complex I Assembly · correlation 0.89
- Transcriptional Elongation Control · correlation 0.88
- Cell Cycle Entry · correlation 0.87
- Interferon Stimulated Response · correlation 0.86
- Mitochondrial ETC · correlation 0.86
- S-phase Replication · correlation 0.84
- DNA Replication Licensing · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.