LDHA — Lactate dehydrogenase A

LDHA belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LDHA's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Glycolysis Biosynthesis Mitochondrial & OxPhos	EIF3I, FABP5, MDH1, MRPL17, PAICS, PKM, POLD2, PRDX1 +4 more	View in SCUBA
CD4⁺ T cells	Ribosome biogenesis Housekeeping	APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LSM5 +17 more	View in SCUBA
Endothelial	Mitochondrial Metabolic Stress Mitochondrial & OxPhos	AFAP1, DHRS7B, MCUR1, MRPL9, NDUFA8, NUCB2, OAZ3, PRKACA +3 more	View in SCUBA
Fibroblasts	ER Stress UPR Stress	ARF4, B4GALT1, BTG3, BZW1, CYCS, EFHD2, ELOC, LITAF +6 more	View in SCUBA
Gamma-delta T cells	Anabolic Activation Response Housekeeping	ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more
Glial cells	RNA Translation Processing RNA processing & translation	CYCS, EEF1B2, EEF1D, HNRNPA1, HNRNPH3, NAP1L1, NPM1, PFDN5 +5 more	View in SCUBA
Goblet cells	Metabolic Stress Response Mitochondrial & OxPhos	ATP6V0B, C11orf24, CHCHD2, COX17, MRPL52, PRDX4, SRA1, TAGLN2 +2 more	View in SCUBA
Innate lymphoid cells	Actin Cytoskeleton Dynamics Cytoskeleton & motility	ACTB, ACTG1, ACTR3, ANAPC11, AP2S1, ARPC5, CALM3, CAPZB +11 more	View in SCUBA
Macrophages	Oxidative Metabolic Program Mitochondrial & OxPhos	ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more	View in SCUBA
Mucosal-associated invariant T cell	ER Stress UPR Stress	DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, MAP1LC3B +9 more
Natural Killer cells	Metabolic Activation Metabolism	FABP5, NCL, NOP56, POMP, PTMA, SERBP1, SLC25A3, SNRPG +2 more	View in SCUBA
Neutrophils	Glycolytic Metabolism Housekeeping	CSTB, CTSD, ENO1, FAM210A, GAPDH, GRN, GSTO1, LGALS3 +4 more
Pericytes	ER Stress Response Stress	ARF4, HSPA5, PDLIM1, RAP1B, REXO2, SEC61G, SELENOS, SNX6	View in SCUBA
Smooth muscle cells	Non-muscle Actomyosin Cytoskeletal	C1R, CAST, CD63, CLIC1, DYNLL1, FILIP1L, LIMS1, MYH9 +4 more	View in SCUBA

About the gene

Chromosome	11: 18394560-18408425
Predicted location	Intracellular
Essential gene	Yes
Protein class	Cancer-related genes, Disease related genes, Enzymes, Essential proteins, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Oxidoreductase

Function

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.