NDUFA8 — NADH:ubiquinone oxidoreductase subunit A8

NDUFA8 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NDUFA8's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Oxidative phosphorylation Mitochondrial & OxPhos	ACADVL, CHMP1A, COX14, EIF2AK1, EML2, ETFA, GPR108, PARP1 +12 more	View in SCUBA
Endothelial	Mitochondrial Metabolic Stress Mitochondrial & OxPhos	AFAP1, DHRS7B, LDHA, MCUR1, MRPL9, NUCB2, OAZ3, PRKACA +3 more	View in SCUBA
Fibroblasts	Mitochondrial OxPhos Mitochondrial & OxPhos	ATP5PF, COX6A1, COX6C, GSTP1, MGST3, NDUFA12, NDUFB10, NDUFB4 +6 more	View in SCUBA
Gamma-delta T cells	Mitoribosome Small Subunit Mitochondrial & OxPhos	ACADM, C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6 +24 more
Innate lymphoid cells	Oxidative Phosphorylation Mitochondrial & OxPhos	APEX1, ATP5F1A, CCNC, COA3, DMAC1, ESD, HDAC2, HINT2 +15 more	View in SCUBA
Macrophages	Mitochondrial Complex Assembly Mitochondrial & OxPhos	COX14, LAMTOR1, MRPL43, NDUFC1, SMIM26, SURF1, TADA3, VPS28	View in SCUBA
Mucosal-associated invariant T cell	Mitochondrial Biogenesis Mitochondrial & OxPhos	ARFRP1, ARL2, ATP6V0E1, CALHM2, CCS, COA4, DBP, DENND2D +15 more

About the gene

Synonyms	MGC793, PGIV
Chromosome	9: 122144058-122159779
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins
Biological process	Electron transport, Respiratory chain, Transport

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.