COMMD4 — COMM domain containing 4
COMMD4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COMMD4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Remodeling DNA/chromatin regulation | ANP32B, ATP5IF1, CALM3, CBX3, HAT1, HMGA1, HMGB1, HNRNPD +9 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | AAMDC, ANP32B, CBX5, CDK4, CKAP4, COQ2, CSE1L, DAZAP1 +18 more | View in SCUBA |
| Gamma-delta T cells | Cellular Homeostasis Housekeeping | ANAPC11, BANF1, CALM3, CBX3, CBX5, DPM2, DUT, FDPS +21 more |
About the gene
| Synonyms | FLJ20452 |
|---|---|
| Chromosome | 15: 75336020-75343224 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin- RING E3 ubiquitin ligase (CRL) complexes. Down- regulates activation of NF-kappa-B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.