MED12L — Mediator complex subunit 12L
MED12L belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MED12L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Erythroid Maturation Signaling Erythropoietic | ATP1B1, ELMO1, GUCY1B1, HTR1F, IGSF10, PLXDC2, PRKACB, SESN3 +3 more |
About the gene
| Synonyms | KIAA1635, TNRC11L, TRALP, TRALPUSH |
|---|---|
| Chromosome | 3: 151085286-151437072 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Molecular function | Activator, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.