GUCY1B1 — Guanylate cyclase 1 soluble subunit beta 1
GUCY1B1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GUCY1B1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Fibroblasts | Complement-producing Fibroblast Inflammatory | ANK2, C3, CLSTN3, CYP7B1, DAAM1, DHRS3, GUCY1A1, LPAR1 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Maturation Signaling Erythropoietic | ATP1B1, ELMO1, HTR1F, IGSF10, MED12L, PLXDC2, PRKACB, SESN3 +3 more | |
| Pericytes | Pericyte ECM Production ECM production | AEBP1, CALD1, COL14A1, LURAP1L, PMP22, SDC2, TPPP3, VCL | View in SCUBA |
| Smooth muscle cells | NO-cGMP Signaling Contractility | AC005884.1, AC068888.1, AL355974.2, DEPP1, GUCY1A1, HIST1H4C, HOTAIRM1, REX1BD +2 more | View in SCUBA |
About the gene
| Synonyms | GC-S-beta-1, GC-SB3, GUC1B3, GUCY1B3 |
|---|---|
| Chromosome | 4: 155758992-155807811 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | cGMP biosynthesis |
Function
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.