Erythroid Maturation Signaling
Gene co-expression module in Hematopoietic progenitor cells
| Category | Erythropoietic |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
TRIM58 is an erythroid-specific E3 ubiquitin ligase that mediates dynein degradation during red cell maturation, directly linking this module to erythropoiesis. ELMO1 mediates cytoskeletal remodeling and phagocytic engulfment (relevant to erythroblastic island macrophage interactions). GUCY1B1 encodes soluble guanylate cyclase beta subunit involved in NO/cGMP signaling, expressed in erythroid and vascular cells. PLXDC2 marks HSC niche interactions. SESN3 (sestrin 3) is a stress-responsive mTOR regulator. PRKACB (PKA) mediates cAMP signaling. ATP1B1 (Na+/K+ ATPase beta-1) maintains ion homeostasis in erythroid cells. ZBTB20 is a TF expressed in erythroid and other hematopoietic cells. TRIM58 firmly anchors this in erythroid differentiation, with additional signaling components.
Genes
ATP1B1, ELMO1, GUCY1B1, HTR1F, IGSF10, MED12L, PLXDC2, PRKACB, SESN3, SLC10A5, TRIM58, ZBTB20
Most correlated modules
- HSC Stemness Program · correlation 0.79
- Oxidative Stress Survival · correlation 0.76
- Erythro-Megakaryocytic Development · correlation 0.72
- HSC Progenitor Proliferation · correlation 0.69
- HSC Stem Identity · correlation 0.65
- Erythroid Progenitor Program · correlation 0.65
- General Metabolic Housekeeping · correlation 0.59
- HSC Quiescence Program · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.