HTR1F — 5-hydroxytryptamine receptor 1F
HTR1F belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HTR1F's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Erythroid Maturation Signaling Erythropoietic | ATP1B1, ELMO1, GUCY1B1, IGSF10, MED12L, PLXDC2, PRKACB, SESN3 +3 more | |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | ACKR3, AFAP1L2, CSRNP3, GJC1, JAG1, LRRC10B, RAP2A, SLC38A11 +3 more | View in SCUBA |
About the gene
| Synonyms | 5-HT1F, HTR1EL |
|---|---|
| Chromosome | 3: 87792706-87993839 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.