SESN3 — Sestrin 3
SESN3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SESN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Interferon Response Anti-viral | ACAP1, ARHGAP15, BCL2, CD44, CD46, DSE, EML4, FCGR2B +7 more | View in SCUBA |
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2 +23 more | View in SCUBA |
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | CNTNAP3B, CYB5RL, FOXO1, IL7, ITSN1, KIF3C, KRT8, LRCH2 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Maturation Signaling Erythropoietic | ATP1B1, ELMO1, GUCY1B1, HTR1F, IGSF10, MED12L, PLXDC2, PRKACB +3 more | |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
About the gene
| Synonyms | MGC29667, SEST3 |
|---|---|
| Chromosome | 11: 95165513-95232541 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.