SCUBA

PLXDC2 — Plexin domain containing 2

PLXDC2 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PLXDC2's module in each cell type

Cell typeModuleShares the module with
EndothelialNF-κB Stress Signaling
Inflammation
AKR1C3, ELK4, EPS15, METRNL, MYCBP2, NFAT5, PALM, PELI2 +4 moreView in SCUBA
EnterocytesEnterocyte identity TFs
Epithelial development
CAMK2G, MALRD1, MAML3, PBX1, SPTLC3, TPD52, TTC17, ZBTB20View in SCUBA
FibroblastsCCL11 Secretory Fibroblast
ECM production
ANK3, ARHGAP24, CCL11, COL16A1, COL18A1, DTX4, F11R, GABRA2 +5 moreView in SCUBA
Goblet cellsGoblet Cell Identity
Epithelial development
CELF2, FOXP1, FRYL, GPRIN3, HOXB13, ITPR2, KCTD12, NEDD4L +5 moreView in SCUBA
Hematopoietic progenitor cellsErythroid Maturation Signaling
Erythropoietic
ATP1B1, ELMO1, GUCY1B1, HTR1F, IGSF10, MED12L, PRKACB, SESN3 +3 more
Innate lymphoid cellsIFN-gamma Response
Inflammation
APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 moreView in SCUBA
Lymphatic endothelialChromatin Remodeling
DNA/chromatin regulation
BAZ2B, CHD9, ITFG1, JMJD1C, MICAL3, MPDZ, PACSIN2, PHKB +4 moreView in SCUBA
MacrophagesEndosomal Vesicle Trafficking
Vesicular traficking
ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 moreView in SCUBA
NeutrophilsEndocytic Vesicle Trafficking
Vesicular traficking
CPQ, NUMB, PACSIN2, PREX1, RBM47, SBF2, TBL1X, TECPR2 +1 more

About the gene

SynonymsFLJ14623, TEM7R
Chromosome10: 19816239-20289856
Predicted locationMembrane
Essential geneNo
Protein classPredicted membrane proteins

Function

May play a role in tumor angiogenesis

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.