ELMO1 — Engulfment and cell motility 1

ELMO1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ELMO1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	T Cell Signaling B cell help	CCDC6, EFNB2, ETS1, MYO5A, PTPN11, RABGAP1L, SFXN1, SH2D1A +4 more	View in SCUBA
Endothelial	IL-13/STAT6 Signaling Inflammation	ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 more	View in SCUBA
Gamma-delta T cells	JNK/MAPK Stress Signaling Stress	ABTB3, BICRAL, COP1, DICER1, ERC1, FBXO11, FCHSD2, FGFR1 +19 more
Hematopoietic progenitor cells	Erythroid Maturation Signaling Erythropoietic	ATP1B1, GUCY1B1, HTR1F, IGSF10, MED12L, PLXDC2, PRKACB, SESN3 +3 more
Lymphatic endothelial	Polarized Vesicle Trafficking migration & adhesion	EXOC4, EXOC6B, IMMP2L, L3MBTL4, LRBA, LRMDA, MYO9A, PARD3B +5 more	View in SCUBA
Mucosal-associated invariant T cell	Calcium Signal Integration TCR Signaling	ANKRD44, ARB2A, CAMK2D, DOCK10, EXOC4, FCHSD2, FNDC3A, FOXN3 +20 more
Neutrophils	ELMO-DOCK Chemotaxis Chemotaxis	BCAS3, CDK19, DOCK2, KMT2C, NCOA2, STAG1, VPS13B

About the gene

Synonyms	CED-12, CED12, ELMO-1, KIAA0281
Chromosome	7: 36852906-37449223
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Apoptosis, Phagocytosis

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.