MMP17 — Matrix metallopeptidase 17
MMP17 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MMP17's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2 +15 more | View in SCUBA |
About the gene
| Synonyms | MT4-MMP |
|---|---|
| Chromosome | 12: 131828393-131851783 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
Function
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.