MN1 — MN1 proto-oncogene, transcriptional regulator
MN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Multipotent Progenitor Identity Stemness | BCL11A, BTG2, DOCK1, DUSP6, NLRP1, PTPRE, SEPTIN9, STARD9 +2 more | |
| Monocytes | Myeloid Epigenetic Regulation Developmental | CYRIA, GPRC5A, H2AC25, MTHFD1L, PCGF5, PDE2A, PPP1R14B, RAPH1 +1 more | View in SCUBA |
About the gene
| Synonyms | MGCR, MGCR1, MGCR1-PEN |
|---|---|
| Chromosome | 22: 27748277-27801756 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Activator, Developmental protein |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.